TNFRII-Fc-IL 1RA
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Official Full Name
TNFRII-Fc-IL 1RA -
Overview
The role of TNF in inflammatory diseases has been well established. TNFRII fused to human IgG1 Fc fragment (trade name Enbrel) has been used for treating certain TNF-dependent disorders such as rheumatoid arthritis and psoriasis. Since TNF alpha and IL-1 are two major players in inflammatory diseases, a fusion or chimeric of a TNF antagonist and an IL-1ra or its functional equivalent can be used to block both TNF alpha and IL-1 pathways, and therefore can be used to treat acute and chronic inflammation-related diseases more effectively than each individually. IL-1ra binds to IL-1 receptors and directs the fused therapeutic agent to IL-1 receptor-rich inflammation site. It also neutralizes IL-1 activity. The fusion of IL-1ra and any of these proteins can be used in treating inflammation, asthma, and angiogenesis-related disorders or endothelial cell proliferation-related disorders. -
Synonyms
IL1RN;interleukin 1 receptor antagonist;DIRA;ICIL-1RA;IL-1RN;IL-1ra;IL-1ra3;TNFRII-Fc;TNF;tumor necrosis factor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TFI-P1007H | TNFRII-Fc-IL 1RA | CHO | Human | Non |
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Involved Pathway
TNFRII-Fc-IL 1RA involved in several pathways and played different roles in them. We selected most pathways TNFRII-Fc-IL 1RA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRII-Fc-IL 1RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
TNFRII-Fc-IL 1RA has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRII-Fc-IL 1RA itself. We selected most functions TNFRII-Fc-IL 1RA had, and list some proteins which have the same functions with TNFRII-Fc-IL 1RA. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
TNFRII-Fc-IL 1RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRII-Fc-IL 1RA here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRII-Fc-IL 1RA.
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